Nutritional diseases are diseases in humans that are directly or indirectly caused by a lack of essential nutrients in the diet. Nutritional diseases are commonly associated with chronic malnutrition. Additionally, conditions such as obesity from overeating can also cause, or contribute to, serious health problems. Excessive intake of some nutrients can cause acute poisoning.

Obesity is caused by consuming too many calories compared to the amount of exercise the body is performing, causing a distorted energy balance. It can lead to diseases such as cardiovascular disease and diabetes. Obesity is a condition in which the natural energy reserve, stored in the fatty tissue of humans and other mammals, is increased to a point where it is associated with certain health conditions or increased mortality.

The low-cost food that is generally affordable to the poor in affluent nations is low in nutritional value and high in fats, sugars and additives. In rich countries, therefore, obesity is oftentimes a sign of poverty and malnutrition while in poorer countries obesity is more associated with wealth and good nutrition. Other non-nutritional causes for unhealthy obesity included: sleep deprivation, stress, lack of exercise, and heredity.

Vitamin poisoning is the condition of overly high storage levels of vitamins, which can lead to toxic symptoms. The medical names of the different conditions are derived from the vitamin involved: an excess of vitamin A, for example, is called "hypervitaminosis A".

Iron overload disorders are diseases caused by the overaccumulation of iron in the body. Organs commonly affected are the liver, heart and endocrine glands.

In some cases, eating too much of one thing can induce an apparent deficiency of something else. A common example occurs when livestock eat locoweed: locoweed contains a toxin that inhibits enzymes, simulating a deficiency of the enzymes.

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